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Thus, in most cases, for the USP14 ligands IU1-248 and 317 , their hydroxyl group was defined as anchor atom, while for the IMPDH2 and CERT1 ligands the anchor atoms were conveniently defined, as shown in Supplementary Fig

These pharmacokinetic limitations explain why the most successful applications have been topical (where the peptide is applied directly to the target tissue) rather than systemic

Treatments for male infertility may include medical, surgical, or assisted reproductive technology (ART) interventions

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Cross-trial comparisons suggest CagriSema may offer the highest pharmacological weight loss achieved to date: Note: Direct cross-trial comparisons have limitations due to differences in populations, trial designs, and durations