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Tamer Coskun, Eli Lilly, United States Updates Copyright 2023 Prez-Arana, Daz-Gmez, Bancalero-de los Reyes, Gracia-Romero, Ribelles-Garca, Visiedo, Gonzlez-Domnguez, Almorza-Gomar and Prada-Oliveira
When trying to establish causality it is important to record the onset and relief of symptoms in relation to the offending drug, and to rule out psychotic conditions
Confidence is Low for human efficacy
For example, because the plasma protein binding of valproate is concentration dependent, the free fraction increases from approximately 10% at 40 mcg/mL to 18.5% at 130 mcg/mL
Additionally, it can slow down gastric emptying, which can increase feelings of satiety and reduce caloric intake
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