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56 Apart from debris removal and resolution of injury, macrophages might play an important and very early role in hepatocyte proliferation after APAP-induced liver injury, based on the facts that macrophages are known to produce mitogens such as HGF, TGF-, platelet-derived growth factor, TNF-, and IL-6 and that proliferation occurs first after APAP toxicity in a layer of hepatocytes surrounding the necrotic zones, where macrophages actively infiltrate and proliferate.12, 22 In contrast, macrophages can also produce mito-inhibitory factors such as TGF-, which inhibits liver regeneration after APAP toxicity

doi: 10.1128/AEM.68.3.1458-1463.2002, 86 ParksD

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Given the limitations and side effects of existing treatments for neuropsychiatric disorders, antioxidant therapy presents a promising, safer alternative

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