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Lastly, patients with heart failure (HF), composite cardiovascular events (i.e., unstable angina, ischemic heart disease, myocardial infarction, coronary stenting, percutaneous coronary intervention (PCI), coronary artery bypass), and clinically significant portal hypertension events (i.e., esophageal varices with and without bleeding, ascites, hepatic failure, hepatorenal syndrome, portal hypertension, liver transplant status, fibrosis, sclerosis and cirrhosis of the liver, hepatic encephalopathy, jaundice) were excluded if they occurred before inclusion to the cohort or prior to the index event

They change how the brain processes hunger, fullness, and the rewarding properties of food at a neurological level

We look for the hidden barriers to weight loss, such as: Insulin Resistance: The inability to process sugar efficiently, leading to fat storage