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Facial flushing and mild skin warmth

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Dose-dependent studies in macrophage models showed significant reductions in tissue inflammation, edema, and osteophyte formation with BV and melittin therapy at concentrations as low as 0.15 g/kg, highlighting its therapeutic efficacy ( BV and melittin also effectively inhibit the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-stimulated RAW 264.7 cells without cytotoxic effects

meanwhile, prolonged intense exercise training has been correlated with a transient decrease in immune system of athletes [106]