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Acknowledgments We thank all authors for their contributions to this study

Yet another small molecule that has been studied extensively as a highly potent small molecule inhibitor of both human and murine CD38 is 78c, which has been shown to be 10-fold less potent against the cyclase activity than the hydrolase activity of recombinant human CD38 139

This is due to the medications action on the digestive system, particularly its effect on slowing gastric emptying, which can lead to increased fermentation of undigested food by gut bacteria, resulting in gas