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doi:10.1016/j.rmed.2020.106064 Sriram KB, Percival M

10.1016/j.nlm.2009.02.004 27 De GasparoM.HusainA.AlexanderW.CattK

GIP, an anabolic hormone, targets your hypothalamus to make you feel full (6)

Sitagliptin works ONLY when blood sugar is elevated, to address diminished insulin levels due to -cell dysfunction and uncontrolled production of glucose by the liver (due to pancreatic -cell and -cell dysfunction) Figure

Harder because: you lack the deep receptor adaptation that higher-dose tirzepatide users have, meaning the GLP-1 and GIP components of retatrutide may hit you harder than expected at relatively low doses