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"Lyophilized pharmaceutical forms: development and regulatory aspects." Drug Discovery Today

Subcutaneous tissue is densely populated with mast cells, and cationic peptides are established activators of the MRGPRX2 receptor on human skin mast cells, triggering degranulation and histamine release through a signalling cascade that has been characterised in some detail in primary human skin mast cells

Adjust implementation based on results and tolerability

Of course, this approach is quite demanding for the patient, who is required to undergo a, even if simple, surgical procedure, but the sensor lifetime makes this system a good and appealing alternative