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In contrast, the mutations significantly reduced the receptor activity when EX4-fused ECD was expressed separately from the TMD, especially for the Q211A/H212A/Q213A, E373A/H374A/A375 and V370A/M371A/D372A mutations, which nearly abolished the receptor activity (Figure 8a and e, expression levels shown in Supplementary Figure S2B and D and the normalized activity shown in Supplementary Figure S3A and C)

FDA identified particular concern for proposed injectable exposure because no clinical immunogenicity or aggregation studies were available

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Khatoon S, Kalam N (2025) Mechanistic insight of curcumin: a potential pharmacological candidate for epilepsy

Moreover, a heterozygotic loss of Cpt2 has been previously shown to delay the postnatal cell cycle withdrawal of mouse cardiomyocytes 36 , supporting the role of the fat-rich diet and fatty-acid metabolism in limiting cardiomyocyte proliferation and regeneration