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Wellbutrin, known generically as bupropion, distinguishes itself in the pharmacological treatment of mental health, particularly in the management of major depressive disorder (MDD) and seasonal affective disorder (SAD)

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Clinicians and researchers have recently emphasized the need to consider frailty and sarcopenicobese phenotypes [132]: frail individuals with high cardiometabolic risk may benefit, whereas anorexic or malnourished phenotypes are vulnerable to excessive weight loss or dehydration [133]

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In a comparison with oral semaglutide for type 2 diabetes , orforglipron performed at least as well in terms of blood sugar control