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This decline is linked to an increase in oxidative stress and cellular damage

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Jan 28 2020;9(2)doi:10.3390/antiox9020116 Guo J, Hao X, Wang R, et al

As with many medical conditions, especially chronic conditions, theres a genetic component and an environmental component

For example, we have them in the gastric stomach, the colon (hence the constipation), pancreas, intestine, lungs, kidneys, heart and even the brain, particularly the areas of the brain involved in impulse control, reward and addiction