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In heterogeneous tumor environments, achieving selective targeting of mutant p53 cells without damaging wild-type p53-dependent normal cells is a major challenge, mainly for the following reasons: some drugs targeting mutant p53 may also be toxic to wild-type p53 cells, and the complex tumor microenvironment may affect the efficacy of drugs

10.1001/jama.290.7.89812928466 3 Futterman LG, Lemberg L

It expects to finance its operations through equity offerings, debt financings or other capital sources, including collaborations with other companies or other strategic transactions

RB: Writing original draft, Supervision, Data curation