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368 Astrocytes exposed to excessive ammonium start to generate aberrant Ca 2+ signals, which may cause excitotoxic release of glutamate

Most patients tolerate peptides extremely well

doi:10.1096/fj.09-142307 Malinda KM, Goldstein AL, Kleinman HK

Down-regulation of SARM1 and TRAF6 reduce the level of PINK1 and then recruits Parkin to the impaired mitochondria, indicating that SARM1 plays a crucial role in mitophagy via modulating PINK1

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