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Clearly more research on TMAO in different disease context as well as longitudinal studies are needed to understand the potential impact of this metabolite on biological systems in health and disease

doi:10.1007/s00330-019-06157-0 18

[DOI] [PMC free article] [PubMed] [Google Scholar] 33.McCarty M.F., DiNicolantonio J.J

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FDA grants interchangeable designation to biosimilars that have demonstrated through specific switching studies that alternating between the reference product and the biosimilar multiple times does not produce different results than staying on either product alone [3]