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1997) and causes differential changes in expression of numerous genes associated with stress response, cell cycle, growth inhibition, cell death, cell structure, cell signalling and inflammation (Priyadarsiny et al

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Systemic administration typically suits joint applications given the difficulty of accessing intra-articular spaces without specialized medical procedures

Prostate cancer cells have also been found to adhere to osteoblasts within the hematopoietic stem cell niche, resulting in TBK1 upregulation, which suppresses mTOR signaling and promotes cellular dormancy and drug resistance 29