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While current evidence does not establish a direct causal relationship between tirzepatide and gastrointestinal bleeding, tirzepatide's known gastrointestinal effectsincluding nausea, diarrhea, vomiting, and constipationmay indirectly contribute to conditions that cause rectal bleeding

Research is ongoing, and results are not yet definitive

Evening injectors sometimes experience nausea while sleeping, which disrupts rest without providing any appetite-suppression benefit since they are not eating anyway

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