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The choice between them depends on whether appetite control or direct metabolic enhancement is the priority

It helps regulate blood pressure and volume by controlling the amount of water retained or excreted by the kidneys

R., Richdale, A., & Trollor, J

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Repurposing and Novel Agents: A pragmatic strategy involves the rapid evaluation of existing IGF-1R inhibitors (e.g., linsitinib from oncology) in pre-clinical PAH models ( Biomarker-Enriched Trials: Future trials should stratify patients based on target expression (e.g., IGFBP-7 levels), combine IGF-axis interventions with standard therapies, and use advanced endpoints such as imaging markers of vascular remodeling