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This study illustrates the importance of inhibiting the glutathione metabolic pathway regulated by Nrf2 for tumor therapy, and at the same time provides a new idea for the treatment of malignant tumors with IDH1 mutations

To clarify this relationship, our group has developed a pharmacological model of CI impairment

Key findings: (1) Aged Fischer 344 rats showed restoration of spatial memory (Morris water maze) after subcutaneous Dihexa treatment at picomolar doses

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