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Interestingly, Phase lll detoxification can often be considered a rate-limiting factor in detoxification due to the fact that intestinal inflammation inhibits elimination of toxins by causing a strong down-regulation of the bodys natural detoxification pathways

In a study on the depigmenting effects of glutathione, Weschawalit et al administered 250 mg glutathione daily, both reduced GSH and oxidized GSSG forms, to 60 volunteers for 12 weeks showing a good depigmenting effect without any adverse effects

[DOI] [PMC free article] [PubMed] [Google Scholar] 89.Takemoto K, Hatano E, Iwaisako K, Takeiri M, Noma N, Ohmae S, Toriguchi K, Tanabe K, Tanaka H, Seo S, Taura K, Machida K, Takeda N, Saji S, Uemoto S, Asagiri M