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During the first several weeks, your digestive system essentially needs to recalibrate to this new signaling environment

10.1016/j.bbrc.2024.149882 51 MederackeI.FilliolA.AffoS.NairA.HernandezC.SunQ.et al (2022)

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Significant Limitations : High costs, access barriers, tolerability issues, and sustainability concerns prevent these agents from achieving their full transformative potential at a population level