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Abbreviations MWM: Morris water maze NOR: Novel object recognition NC: Normal control HY: Hypobaric hypoxia ADORA1: Adenosine A1 receptor ADORA2A: Adenosine A2A receptor ADORA2B: Adenosine A2B receptor ADORA3: Adenosine A3 receptor qPCR: Quantitative Real-time Polymerase Chain Reaction ELISA: Enzyme-linked immunosorbent assay RNA-seq: RNA sequencing BBB: Blood-brain barrier EPAC1: Exchange protein directly activated by cAMP1 VDAC1: Voltage-dependent anion channel 1 cGAS: Cyclic GMP-AMP synthase STING: Stimulator of interferon genes GPCRs: G protein-coupled receptors NLRP3: Nucleotide-binding domain-like receptors protein 3 GRP75: Glucose regulated protein 75 IP3R1: Inositol 1,4,5-trisphosphate receptor type 1 IRF3: Interferon regulatory factor 3 p-IRF3: Phospho-Interferon Regulatory Factor 3 HO-1: Heme oxygenase 1 ZO-1: Zonula occludens-1 GAPDH: Glyceraldehyde-3-Phosphate Dehydrogenase ACTB: Beta-actin BDNF: Brain derived neurotrophic factor SYN1: Synapsin 1 ARC: Activity regulated cytoskeleton associated protein TOM20: The outer membrane translocase 20 Nrf2: Nuclear Factor Erythroid 2-Related Factor 2 NeuN: Neuron-specific nuclear protein NF-B: Nuclear factor kappa-B cAMP: Cyclic adenosine monophosphate MPTP: Mitochondrial permeability transition pore mtDNA: Mitochondrial DNA PSD: Postsynaptic density MAPK: Mitogen-activated protein kinase ATP: Adenosine Triphosphate D-loop3: Displacement loop3 COX1: Cyclooxygenase 1 mt -ND1: Mitochondrially encoded NADH dehydrogenase subunit 1 IL-1: Interleukin-1 IL-6: Interleukin-6 IL-18: Interleukin-18 TNF-: Tumor necrosis factor- MDA: Malondialdehyde GSH: Glutathione SOD: Superoxide dismutase CAT: Catalase H&E: Hematoxylin and eosin PBS: Phosphate Buffered Saline EB: Evans blue TEM: Transmission electron microscopy PMSF: Phenyl methane sulfonyl fluoride DG: Dentate gyrus CA3: Cornu Ammonis area 3 References Ma, Y