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Primary carnitine deficiency PCD is a rare genetic disease caused by mutations in the SLC22A5 gene, which leads to dysfunction of the carnitine transporter OCTN2, thereby hindering the entry of carnitine from the blood into cells and the reabsorption of carnitine by the kidneys

the NHS provides B12 shots based on clear clinical need, so the blood test is the crucial first step to getting a prescription

Anaphylactic shock and death have been reported after parenteral Vitamin B12 administration

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Results Emulating pivotal cardiovascular outcome trials and expanding populations To validate our analytical framework, we emulated the cardiovascular outcome trials SUSTAIN-6 and SURPASS-CVOT using three national claims databases from the USA