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doi: 10.1038/ncomms7528 54 FernandezM

Based on mouse strain differential susceptibility to phenobarbital promotion of DEN-initiated hepatocarcinogenesis, the authors compared the effects of phenobarbital in drinking water on hepatic microsomal protein concentrations in four strains of mice

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Researchers should avoid assuming that a mechanism observed in one tissue necessarily explains all effects in another tissue

Specific digestive enzymes, most notably gamma-glutamyltransferase (GGT) and various intestinal peptidases, cleave the tripeptide into its constituent amino acids long before it can reach systemic circulation intact