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Furthermore, it was hypothesized that the peptide may have potentially contributed to enhanced cholesterol profiles and improved glucose tolerance

10.1186/s12916-022-02599-4 179 WHO (2023)

SLEEP Advances , 6(4), zpaf082

Non-genomic pathways enhance its protective role: Vit D has shown to stabilize mitochondrial function, relieve oxidative stress by activating the Nrf2 pathway, and modulate synaptic plasticity through stimulation of neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) 28

In addition, tissue levels of malondialdehyde (MDA), a lipid peroxidation marker, were reduced in DMF treated SCD mice than control mice (Fig