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An underactive thyroid slows down metabolic processes, leading to fatigue, weight gain, cold intolerance, and sluggishness. The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDKD) reports that hypothyroidism is more common than hyperthyroidism and is often linked to the autoimmune disorder Hashimotos disease

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Similarly, folate requirements rise during active cell division, and inadequate folate can limit the effectiveness of B12 therapy