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The safest approach is to follow the recommended dosage, typically 250500 mg per day
According to a previous study, the co-supplementation of vitamin E effectively ameliorates the low toxicity threshold of Se ( GSH, an endogenous antioxidant synthesized from different amino acids including glycine, cysteine, and glutamate, effectively inhibits oxidative stress-related damage and altered ROS production level (30, 31)
Figure 5 In some systematic reviews and meta-analyses, the publication dates of the included studies were relatively early and the intervention dosages maybe unreasonable