3.8.2 Autophagy Autophagy is the key to maintain the stability of the intracellular environment, and is also a stress-responsive mechanism in pathophysiological conditions
G Immunoblot assay of phosphorylated and total ERK1/2 as well as cell cycle related proteins (Cyclin D1, CDK4 and CDK6) in BPH-1 and WPMY-1 after GPX3 overexpression or U0126 treatment
Increases in the expression of various molecules that have been noted in reactive astrocytes across multiple contexts include GFAP, vimentin, nestin (probably labelling proliferating astrocytes), synemin plectin, -crystallin B chain, monoaminoxodase-B (MAO-B), heat shock factor binding protein 1, complement C3, lipocalin 2, C-X-C motif chemokine ligand 10, SerpinA3N, LCN2 and others, 20,95,96,97,98,99,100,101,102,103 but it important to note that no single molecular marker (including GFAP) is an absolute, required and sufficient, indicator of astrocyte reactivity, and no molecular markers have yet been identified that reliably distinguish amongst different reactive astrocyte phenotypes
Hjberg PV, Vilsbll T, Rabl R et al
Novo Nordisk is also investigating a triple agonist of GLP-1, GIP, and glucagon receptors