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Each is the latest step in a distinct multi-decade research lineage, and understanding those lineages explains why the two look so different despite chasing the same endpoint

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Decreased mRNA expression or protein levels for TGF1, TGFBR1 [41], SMAD3 [42], SMAD6 [43], and SMAD7 [41, 43] have been reported in more advanced stages of COPD or fibroblasts from COPD patients

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