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But cost, tolerability, side-effect profiles, and individual response all factor in
Nausea, vomiting, and constipation are most common, especially during initial dose titration, and typically improve over time
Furthermore, a coherent alteration of the lysine catabolism was recently observed in diurnal metabolic pathways impacted by high-fat diet, suggesting that fructose intake can similarly exacerbate the alteration of amino acid metabolism [60]
In terms of the mechanism of action, statins can act on the calcium channel subunit Cacna2d3 to reduce calpain 1-mediated myocardial mitochondrial apoptosis, thereby exerting a protective effect against myocardial ischemia-reperfusion injury
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