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Benefits reported from use of B12 include improved sleep, reduced allergies, reduced stress and depression, improved mood, and less frequent or severe headaches

The exact mechanism is not fully understood, but gastrointestinal effects and possible changes to saliva composition may contribute to metallic, bitter, or unpleasant taste sensations

placebo at 6 months] 1.3, 95%CI 0.891.88) in 300 people with HF, with and without type 2 diabetes and with recent decompensation (Margulies et al., 2016)

In adults with obesity and type 2 diabetes, the higher dose demonstrated a mean weight loss of 14.1%, while blood sugar-lowering effects (A1C reduction) were similar to those seen with the lower 2.4 mg dose

Dig Dis Sci1989 May;34(5):703-8