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The Role of Lifestyle Modifications Healthy Eating : Adopting a balanced diet rich in whole foods, fruits, vegetables, lean proteins, and healthy fats can enhance the effectiveness of GLP-1 medications

supervised exercise can strengthen periarticular muscles and reduce joint loading Topical NSAIDs (e.g., topical diclofenac) as a preferred first-line pharmacological option for localised joint pain, particularly in older adults where systemic NSAID use carries greater risk Paracetamol is not routinely recommended by NICE for osteoarthritis-type pain but may be considered for short-term use if other options are unsuitable or not tolerated [15] [16] Cold or warm compresses for symptomatic relief If oral NSAIDs are considered necessary, they should be used at the lowest effective dose for the shortest possible duration, on medical advice, and with gastroprotection (a proton pump inhibitor) as recommended by NICE

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Retatrutide: GI adverse events dose-dependent

These are the kinds of considerations that make the initial water volume choice so important