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Using gene-edited mice with humanised GLP-1 receptors, the team found that oral small-molecule GLP-1 drugs activated the central amygdala, a region associated with desire and reward that sits deeper in the brain than the hypothalamic and hindbrain networks where injectable peptide GLP-1s have been shown to act

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Reference only adjust per patient anatomy and clinical judgement What is Saxenda and how does it work?+ Saxenda is a prescription weight-management medicine whose active substance is liraglutide, a GLP-1 (glucagon-like peptide-1) receptor agonist