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Despite being made by the same manufacturer (Novo Nordisk), they serve different clinical purposes

The American Diabetes Association (ADA) 2026 guidelines recommend semaglutide in patients with advanced CKD without specifying eGFR cutoffs and note that its glucose-lowering effect is preserved at low eGFR levels, in contrast to SGLT2 inhibitors, whose glycemic efficacy diminishes with declining kidney function ( In our cohort, semaglutide use was associated with a modest reduction in HbA1c (0.31 2.57%, p = 0.630) and a numerically large but statistically non-significant reduction in body weight (12.63 24.03 kg, p = 0.074)

This medicine may cause your blood sugar levels to rise or fall

There are a few different types