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Impact of berberine hydrochloride-assisted metformin on the metabolism of glycolipids and serum levels of TIMP-1 and TGF-1 in individuals with type 2 diabetes

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We hypothesize that the combination of the lack of Wnt ligands, which are short-range signal molecules, and the presence of Wnt inhibitors such as DKK4, which are long-range signal molecules, at the embryonic niche location is the main reason contributes to the emergence of a Wnt/-catenin signaling free zone in upper hair peg

Coluzzi et al., 2019