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If someone is unwilling to track their progress or adjust based on how their body responds, the medication will be less effective

Oral semaglutide is best suited for adults as part of a holistic weight management plan, incorporating diet and exercise

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Average weight loss in 1 year is 20% (vs 3.1% with diet and exercise alone) in non-diabetics with obesity, or with overweight plus a weight-related condition, with diet and exercise

Nat Rev Endocrinol 21:230244 Hosseinkhani F, Hosseinifar S, Tabandeh MR (2024) Dimethyl itaconate mitigates histological distortions, inflammation, and oxidative stress in PCOS rat model