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These symptoms typically emerge when doses increase and diminish as the body adjusts

Diabetes Care 2006

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This paper extends our current knowledge of the effectiveness of this class of medications. Weighing benefits and risks The greatest risk increases were seen for nausea and vomiting, kidney stones, gastroesophageal reflux disease or GERD, sleep disturbances and non-infectious gastroenteritis, which is inflammation of the digestive tract which can cause nausea, vomiting, diarrhea and stomach cramps

If you find that taking metformin and a GLP-1 together is causing too much nausea, you can easily reach out to the team to discuss adjusting your plan