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[15] The resulting DSIP-CBBBP construct outperformed unmodified DSIP on neurotransmitter restoration in the mouse model, which is the clearest available statement of the problem: the peptide had to be rebuilt to get where it was supposed to act

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When we run IGF-1 on these patients at intake, the labs confirm what they reported: no meaningful elevation from baseline, no evidence the pituitary responded to the therapy at all