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Many suitable candidates have experienced significant antipsychotic-associated weight gain, prediabetes, or established type 2 diabetes while remaining psychiatrically stable

Novel GLP-1R agonists currently under development include HRS9531, a dual GLP-1/GIP receptor agonist being evaluated in overweight or obese individuals with T2DM, which has shown promising results in a Phase 2 study [172]

Reduces Inflammation Excess body fat and insulin resistance contribute to chronic inflammation, which can cause fatigue

The foundation built during months 1-3 pays dividends as side effects fade while appetite suppression remains strong

METTL3-mediated N6-methyladenosine modification stimulates mitochondrial damage and ferroptosis of kidney tubular epithelial cells following acute kidney injury by modulating the stabilization of MDM2-p53-LMNB1 axis