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Indeed, there are still considerable unmet needs in RA management, and new safe treatment approaches that complement the existing ones are required (Smolen et al., 2016)

The post-menopausal women using hormone replacement therapy (HRT) have been reported to have 5% greater muscle strength than those not using HRT ( vastus lateralis muscle samples of nine healthy monozygotic female twin pairs (5462-years old) discordant for HRT showed that miR-182 and miR-223 were significantly downregulated in HRT treated groups as compared to non-treated groups (Olivieri et al., 2014)