BCAA metabolism can influence the concentrations of other amino acids, including Ser (11), -ketoglutarate (-KG) produced by BCAA decomposition is not only an intermediate in the tricarboxylic acid (TCA) cycle, but also indirectly regulates the supply of 3-phosphoglycerate (3-PG), a substrate synthesized by Ser
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doi: 10.1016/S0015-0282(03)00404-7 51 ManciniALeoneEFestaRGrandeGSilvestriniADe MarinisLet al
Am J Clin Nutr 96:8089 Sogut S, Zoroglu SS, Ozyurt H, Yilmaz HR, Ozugurlu F, Sivasli E, Yetkin O, Yanik M, Tutkun H, Savas HA, Tarakcioglu M, Akyol O (2003) Changes in nitric oxide levels and antioxidant enzyme activities may have a role in the pathophysiological mechanisms involved in autism
Vitamin C, in particular, works closely with glutathione in the antioxidant recycling process