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2.5.3 Functio laesa: systemic organ damage SLE-associated systemic inflammation leads to damage in organs such as the heart, lungs, and liver, particularly in patients with hematological symptoms like leukopenia or thrombocytopenia due to the circulation and accumulation of auto-antibodies and inflammatory mediators throughout the body (330)

Compounded formulations may have shorter room-temperature windows

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Helicase enzyme unwinds the duplex to form mature miRNA strands

Overall, the Panel judged that these findings provided some certainty that the balance between benefits and risks/burdens on average is relatively equal and that, similar to other oral treatments, oral PPS may benefit only a subset of patients not readily identifiable a priori