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There was evidence of a significant reduction in average loop diuretic dose, a lower likelihood of diuretic treatment escalation, and a greater likelihood of diuretic treatment de-escalation with semaglutide versus placebo parameters that indicate disease-modifying effects of semaglutide, and are associated with better long-term clinical outcomes in this patient population. Kavita Sharma, MD, study author In this secondary analysis of the STEP-HFpEF program data, researchers found that both male and female participants experienced notable improvements in heart failure symptoms, physical limitations, and exercise

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Around 55% of the blood is plasma