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Compound 12 , when compared to allopurinol and febuxostat, also demonstrated good performance in Caco2 permeability, intestinal absorption, bloodbrain barrier penetration, and plasma protein binding, which suggests its good absorption and distribution capacity

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107 A statistical analysis of three randomized controlled trials with a combined total of 168 participants found curcumin supplementation, at doses of 5001,500 mg per day, led to improvements in fasting glucose, insulin levels, measures of insulin sensitivity, and HDL- and total cholesterol in women with PCOS