A large proportion (47%) of germline mutations in SDHA has been reported in gastrointestinal stromal tumors [116]
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Hyperuricemia and urate nephropathy in urate oxidase-deficient mice
Combinative treatment of -elemene and cetuximab could induce ferroptosis of KRAS-mutant colorectal cancer cells (CRC) by iron-dependent ROS accumulation, GSH depletion, lipid peroxidation, upregulation of HO-1 and transferrin, and downregulation of negative regulatory proteins for ferroptosis (GPX4, SLC7A11, FTH1, glutaminase, and SLC40A1), thus inhibiting tumor growth and lymph node metastases in vivo ( Curcuma zedoaria [Zingiberaceae
The results of in vitro experiments suggested that ALCAR might be partially hydrolyzed upon intestinal absorption (11)