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2931 The mtDNA forms histone-free protein-DNA complexes, referred to as nucleoids, with 68 nucleoids tethered together forming foci
Foster, H
Proteins are far too large to pass through the skin barrier
Pretomanid (the 'Pa' in BPaLM) is a nitroimidazooxazine with activity against both actively replicating and non-replicating/persister TB bacilli this dual bactericidal and sterilizing activity is pharmacologically distinct from bedaquiline and linezolid, making the combination mechanistically synergistic rather than redundant
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