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Several research teams have targeted GSH synthesis inhibitors as potential therapeutic agents

"Tyrosinase is an enzyme that is critical in creating the pigment, or melanin, in our skin," says Heather Woolery-Lloyd, MD, a board-certified dermatologist in Miami

Tsai, N

In human retinal capillary endothelial cells (HRCECs) exposed to HG, TRIM46 induces ferroptosis by promoting GPX4 ubiquitination and degradation, leading to GSH depletion and lipid peroxidation

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