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Thyroid cancer cells also over-express the insulin receptor (IR), especially isoform IR-A
Our findings do not exclude a positive role for endosomal signaling or -arrestin-1 recruitment in acute responses to physiological GLP-1, but highlight how the kinetic context must be taken into account when exploiting noncanonical pathways during drug development
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The combination group showed 1.3 kg greater fat mass reduction measured via DEXA scan, though the difference did not reach statistical significance (p=0.08)
1: where R max is the highest possible response of binding between the analyte and the protein, R protein is the change in response by the immobilization of the protein, M r represents the mass of the analyte or protein, and V protein represents the number of binding sites on the protein
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