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Companies operating in this space should take these developments seriously, review their compliance programs immediately, and prepare for a regulatory landscape that will only become more demanding in the months ahead

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Co-culture experiments with PC3 WT and GGT1 + cell lines were performed using 6-well (24 mm) PET inserts with 0.4 m pores (VWR, 76313-902 or Corning, 354570)

None of the above is a substitute for evaluation by a licensed clinician

The following adverse reactions have been associated with the abrupt discontinuation of the individual components of QSYMIA: For topiramate, abrupt discontinuation has been associated with seizures in patients without a history of seizures or epilepsy [see Warnings and Precautions (5.9)]