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In conclusion, we found that metformin may alleviate the pathological progression of OA primarily by activating Nrf2 signaling pathway, thereby confirming the promising potential of metformin as a treatment paradigm for OA

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Notably, both the combination group ( P = 0.0337

An additional C-terminal Strep-tag was added by overhang PCR amplification with phosphorylated primers, followed by ligation