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A 72-week, double-blind phase 2 trial showed that once-daily administration of semaglutide had a significant therapeutic effect on NASH (193)

GIP receptor activation in the hypothalamus reduces food intake through mechanisms that are distinct from and complementary to GLP-1 pathways

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Growth hormone secretagogues, like those studied in the CJC-1295/Ipamorelin research guide, target the GH/IGF-1 axis rather than incretin pathways and may be studied alongside GLP-1 class compounds for their complementary effects on body composition

Although we adjusted for a wide range of baseline clinical and demographic characteristics, the possibility of residual confounding by unmeasured factors, such as lifestyle, frailty, or socioeconomic status, remains